Research & Articles


Research: Prostate animal exercise study published in JAP

ABSTRACT

Purpose: To investigate the effects of exercise on cancer progression, metastasis, and underlying mechanisms in an orthotopic model of murine prostate cancer.

Results: Primary tumor growth rate was comparable between groups but expression of prometastatic genes was significantly modulated in exercising animals with a shift towards reduced metastasis…

Conclusion: Exercise-induced stabilization of HIF-1α and subsequent upregulation of VEGF was associated with ‘productive’ tumor vascularization with a shift towards suppressed metastasis in an orthotopic model of prostate cancer.

Jones LW, Antonelli J, Masko EM, Lascola CD, Dewhirst MW, Dyck JRB, Nagendran J, Flores CT, Betof AS, Young ME, Nelson ER, Pollak M, Barry WT, Broadwater G, Freedland SJ. Exercise modulation of the host – tumor interaction in an orthotopic model of murine prostate cancer. Journal of Applied Physiology, 2012; PMID: 22604887. See the Research Article here

Comments Closed

Comments are closed. You will not be able to post a comment in this post.

©2005-2019Sunflower Wellness Our thanks for Logo design: William Salit Design Sunflower Wellness is a 501(c)(3) nonprofit corporation based in San Francisco, CA
Sunflower Wellness will be forever grateful to Kimberly Powell for designing our website, and for additional design direction from Jason Herrick and Cecelia Ottenweller.